Jose Mourinho’s men will be eager to get back to winning ways Tuesday night when they host Swiss side Young Boys at Old Trafford.
United, sitting 2nd in Group H after four games, are the only team yet to score at home in this season’s Champions League.
But the Red Devils will book their place in the knockout stages with a defeat of Young Boys and if Valencia fail to beat Juventus in Turin.
The squad can take some comfort in the fact they defeated their Swiss visitors back in September with a 3-0 away win and the homeside are favourites to win.
Despite a fresh start after the international break, Utd only managed a goalless draw with struggling Crystal Palace on Saturday, which left them 14 points behind Premier League leaders Manchester City.
With a mere three wins from nine home matches in all competitions left the Portuguese coach has been left questioning his player’s hearts.
Mourinho has scoffed at suggestions his players find it easier to play away and that playing at Old Trafford brought added pressure
“If you feel pressure stay at home – and when I say home, I don’t say stadium home, I say home and watch it on TV,” he said.
“If you feel pressure to play at home where people come to support, come on. I never feel pressure at home. If you ask me if I prefer to go back to Bern or play at home, I will always say I prefer to play at home.
“What I want is a team to start strong, not to be waiting, not to be reactive.
“Probably you thought Jose told them to start slow, to play nice and easy and see what happens or to be losing. It is exactly the opposite. I want them to start strong and go for it almost immediately.”